Isothiocyanates in Brassica: Potential Anti Cancer Agents
نویسندگان
چکیده
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anti-carcinogenic activity because they reduce activation of carcinogens and increase their detoxification. This minireview summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents.
منابع مشابه
Chemoprotection against cancer by isothiocyanates and glucosinolates.
Introduction Organic isothiocyanates (R-N=C=S) and glucosinolates, their biosynthetic precursors in plants, are attracting increasing attention as chemical and dietary protectors against cancer. More than 20 natural and synthetic isothiocyanates and several glucosinolates have been shown to block chemical carcinogenesis in animal models (see reviews in [1,2]); moreover, these substances are wid...
متن کاملHealth Promoting Effects of Brassica-Derived Phytochemicals: From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation
A high intake of brassica vegetables may be associated with a decreased chronic disease risk. Health promoting effects of Brassicaceae have been partly attributed to glucosinolates and in particular to their hydrolyzation products including isothiocyanates. In vitro and in vivo studies suggest a chemopreventive activity of isothiocyanates through the redox-sensitive transcription factor Nrf2. F...
متن کاملIsothiocyanates: A Chemical Class of Potential Nutraceuticals
Isothiocyanates comprise the most promising class of chemopreventive phytochemicals. They are encountered at substantial amounts in cruciferous vegetables where they exist in the form of glucosinolates. Epidemiological studies have linked consumption of isothiocyanates to low cancer incidence at a number of sites. Furthermore, laboratory studies in animal models of cancer have established that ...
متن کاملTherapeutic Potential of Brassica oleracea (Broccoli) - A Review
Broccoli, Brassica oleracea, variety Italica, belongs to the family Brassicaceae. Broccoli is a fast growing annual plant that grows 6090 cm tall. They are native to the eastern Mediterranean and Asia Minor, and were later introduced to England and America in the 1700s [1] Figure 1. Plants in general, are known to be extremely rich in a variety of secondary metabolites that are found to possess...
متن کاملEffect of cooking brassica vegetables on the subsequent hydrolysis and metabolic fate of glucosinolates.
The protective effects of brassica vegetables against cancer may be partly related to their glucosinolate content. Glucosinolates are hydrolysed by plant myrosinase following damage of plant tissue. Isothiocyanates are one of the main groups of metabolites of glucosinolates and are implicated in the preventive effect against cancer. During cooking of brassica the glucosinolate-myrosinase system...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Asian Pacific journal of cancer prevention : APJCP
دوره 17 9 شماره
صفحات -
تاریخ انتشار 2016